How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals
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چکیده
منابع مشابه
Toll-like receptors in innate immunity.
Functional characterization of Toll-like receptors (TLRs) has established that innate immunity is a skillful system that detects invasion of microbial pathogens. Recognition of microbial components by TLRs initiates signal transduction pathways, which triggers expression of genes. These gene products control innate immune responses and further instruct development of antigen-specific acquired i...
متن کاملToll-like Receptors and Innate Immunity
Toll-like receptors (TLRs) are the best-characterized membrane-bound receptors in innate immune cells, including macrophages and dendritic cells. Upon recognition of specific ligands originating from pathogenand modified selfderived molecules, TLRs trigger intracellular signaling cascades that involve various adaptor proteins and enzymes, resulting in the generation of proinflammatory and antim...
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The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4 are being implicated in the pathology of rheumatoid arthritis, ankylosing spo...
متن کاملToll-like Receptors and NOD-like Receptors in Innate Immune Defense during Pathogenic Infection
In response to invading pathogens, the body immune system develops an immediate defense mechanism, i.e., innate immune response, which is detected in almost all living organisms including mammals, plants, insects, etc. Recent studies have identified numerous innate immune receptors that are able to recognize pathogen-associated molecular patterns and transduce the essential intracellular signal...
متن کاملToll-like receptors, innate immunity and lung transplantation.
Lung transplant allografts have the highest rate of rejection and shortest graft survival time among the commonly transplanted solid organs despite high levels of immunosuppression. This observation strongly indicates that mechanisms unique to the lung allograft contribute to rejection post lung transplant. Unlike most other solid organ recipients, the lung allograft is exposed to both the exte...
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ژورنال
عنوان ژورنال: Journal of Endotoxin Research
سال: 2005
ISSN: 0968-0519
DOI: 10.1177/09680519050110060301